Thermo Fisher Scientific Human EGFR Fc Chimera Recombinant Protein
인간 EGFR Fc 키메라 재조합 단백질로, HEK293 세포에서 발현된 고순도(>97%) 단백질입니다. ELISA, Western blot, IHC 등 다양한 기능적 분석에 사용 가능하며, EGFR-리간드 결합 연구에 적합합니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- ELISA: Assay-dependent
- Functional Assay: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | HEK293 cells |
| Amino Acid Sequence | Human EGFR, amino acids Met1–Ser645 (Accession # NP_005219) with a C-terminal human IgG1 Fc-tag |
| Tag | Fc-tag |
| Molecular Weight | 95 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >97% (SDS-PAGE), >85% (SEC-HPLC) |
| Endotoxin Concentration | <1.0 EU/µg |
| Activity | Measured by its binding ability in a functional ELISA. Immobilized recombinant human EGF at 10 µg/mL (100 µL/well) can bind human EGFR with a linear range of 0.64–400 ng/mL. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4, with 5% trehalose, 0.01% Tween 80, 5% mannitol |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient |
Product Specific Information
Reconstitution:
Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer, making EGFR a target for both biological and small molecule therapeutics.
EGFR is encoded by the EGFR gene located on chromosome 7 in humans and belongs to the HER/ERbB family of proteins, which includes ERbB2, ERbB3, and ERbB4.
EGFR acts as a transmembrane receptor; binding of ligands such as EGF or TGF-α to its extracellular domain triggers dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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