Thermo Fisher Scientific FERMT3 Monoclonal Antibody (OTI3C7), TrueMAB
FERMT3 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P)에서 검증됨. 인간 시료에 반응하며, TrueMAB 형식으로 고순도 정제. 혈소판 및 백혈구의 인테그린 활성화 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 259–528 of human FERMT3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The three KINDLINs are a novel family of focal adhesion proteins that localize to integrin adhesion sites. These proteins contain a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain.
KINDLIN1 and KINDLIN2 are essential for integrin-mediated adhesion and spreading, whereas KINDLIN3 is restricted to hematopoietic cells and is abundant in megakaryocytes and platelets.
Studies have reported transcriptional misregulation of KINDLINs in various cancers. KINDLIN3 is crucial for platelet integrin activation and outside-in signaling, making it a potential target for therapeutic strategies aimed at modulating integrin activation in platelets and leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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