Thermo Fisher Scientific FERMT3 Monoclonal Antibody (OTI2H10), TrueMAB
FERMT3 단백질을 인식하는 마우스 모노클로날 항체로, Western blot 및 IHC(P) 검증 완료. 인간 시료에 반응하며, 액상 형태로 1 mg/mL 농도 제공. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol 완충액에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 259–528 of human FERMT3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The three KINDLINs are a novel family of focal adhesion proteins that localize to integrin adhesion sites. The KINDLIN proteins contain a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain.
KINDLIN1 and KINDLIN2 are essential for integrin-mediated adhesion and spreading, whereas KINDLIN3 is restricted to hematopoietic cells and is abundant in megakaryocytes and platelets.
Dysregulation of KINDLINs has been reported in various cancers. KINDLIN3 is essential for platelet integrin activation and outside-in signaling, making it a potential therapeutic target for modulating integrin activation in platelets and leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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