Thermo Fisher Scientific CEA Monoclonal Antibody (26/3/13)
CEA (CEACAM5) 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal antibody. Western blot, IHC(F), Flow cytometry, ELISA에 사용 가능. 액상형, 2 mg/mL 농도, 4°C 또는 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 4 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 1.2 µg/1x10^6 cells |
| Flow Cytometry (Flow) | 1.2 µg/1x10^6 cells |
| ELISA | 1:200–1:400 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 26/3/13 |
| Immunogen | Extracted protein of human CEACAM5 (CD66e, UniProt ID: P06731-1, antigen range: 1–702) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073300 |
Product Specific Information
This antibody recognizes native human CEACAM5 protein expressed in transfected mammalian cells.
Target Information
CEA (Carcino Embryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors. It belongs to the immunoglobulin supergene family, consisting of one N domain and six constant-like domains (A1–A3, B1–B3).
Antibodies to CEA help identify the origin of metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (60–70% CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA is a glycoprotein tumor marker found in adenocarcinomas of endodermally derived digestive epithelium and fetal colon. The CEA family includes cell adhesion molecules and pregnancy-specific glycoproteins located on chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in this cluster.
Originally described in bile ducts as biliary glycoprotein, CEA is a cell-cell adhesion molecule found on leukocytes, epithelia, and endothelia. It mediates homophilic and heterophilic interactions and is implicated in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants exist, but their full-length nature has not been fully defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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