Thermo Fisher Scientific HLA-Pan (MHC II) Recombinant Rabbit Monoclonal Antibody (HLA-Pan, 2967R)

Thermo Fisher Scientific HLA-Pan (MHC II) Recombinant Rabbit Monoclonal Antibody (HLA-Pan, 2967R)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
Three loci (DR, DQ, DP) encode the major expressed products of the human class II region. Human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in initiating the immune response.

HLA and MHC antibodies are important in Immunopeptidomics, aiding in the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: RBM1-2967-P1_HLA-DRDPDQ_P01911-1_Rabbit.svg, RBM1-2967-P1_HLA-DRDPDQ_P01911-1_Rabbit_PDP.jpeg, RBM1-2967-P1_HLA-DRDPDQ_P01920-1_Rabbit.svg, RBM1-2967-P1_HLA-DRDPDQ_P01920-1_Rabbit_PDP.jpeg, RBM1-2967-P1_HLA-DRDPDQ_P04440-1_Rabbit.svg, RBM1-2967-P1_HLA-DRDPDQ_P04440-1_Rabbit_PDP.jpeg)