Thermo Fisher Scientific IRF7 Monoclonal Antibody (MNGPKL), PE, eBioscience
마우스 IRF7 단백질을 인식하는 MNGPKL 클론 단일클론 항체로, PE 형광표지되어 세포내 염색 및 유세포분석에 적합. 항바이러스 반응 연구용으로 사용되며, 4°C 암소 보관. 친화크로마토그래피로 정제된 고순도 제품.
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Thermo Fisher Scientific IRF7 Monoclonal Antibody (MNGPKL), PE, eBioscience™
Applications
- Flow Cytometry (Intracellular staining)
Tested Dilution: 0.25 µg/test
Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MNGPKL |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572628 |
Product Specific Information
The monoclonal antibody MNGPKL reacts with mouse interferon regulatory factor 7 (IRF7), a 54 kDa transcription factor essential for induction of the antiviral innate immune response and IFN alpha production.
IRF7 is constitutively expressed in B cells, plasmacytoid dendritic cells (pDC), and monocytes, and is activated by viral infection, double-stranded RNA, or Toll-like receptor (TLR) signaling.
Activation via CpG ODNs or single-stranded RNA (recognized by TLR9 and TLR7) promotes IRF7 phosphorylation and nuclear translocation, forming homodimers that drive transcription of type I interferon genes.
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Tested by intracellular staining and flow cytometric analysis of stimulated mouse splenocytes using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) according to BestProtocols®: Protocol A.
- Recommended usage: ≤ 0.25 µg per test (100 µL final volume)
- Cell number range: 10⁵–10⁸ cells/test
- Carefully titrate for optimal performance
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Interferons (IFNs) mediate immune interactions during viral infections and regulate innate and adaptive antiviral mechanisms.
During infection, IRF7 acts as a transcriptional activator of virus-inducible genes, including interferon beta chain genes.
IRF7 interacts with TLR adaptor proteins (MyD88, TRIF/TRAM) and functions in TLR4 and TLR9 signaling.
At least four alternatively spliced isoforms of IRF7 exist, though their specific roles remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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