Thermo Fisher Scientific IL-8 (CXCL8) Polyclonal Antibody

Thermo Fisher Scientific IL-8 (CXCL8) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to cell surface receptors IL-8RA and IL-8RB and functions as a chemoattractant and potent angiogenic factor.
Expression and secretion of IL-8 can be induced by various inflammatory stimuli in macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
IL-8 was first isolated from osteosarcoma cells and contains the ELR motif (N-terminal Glu-Leu-Arg sequence). It signals through CXCR1 and CXCR2 receptors.
Previous names include neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C.
IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster mapped to chromosome 4q.
Cancer studies have shown IL-8’s role in angiogenesis and tumor growth, and it is implicated in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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