Thermo Fisher Scientific CD34 Monoclonal Antibody (1H6), FITC
개 및 혈액줄기세포 연구용 CD34 단클론 항체(FITC 결합형). 유세포분석(FACS)에 적합하며, 단백질 A로 정제된 액상 형태. 4°C 보관, 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow): Neat-1:10
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1H6 |
| Immunogen | Canine CD34 fusion protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2074489 |
Additional Formats
- Biotin (Cat. MA5-28354)
- PE (Cat. MA1-81855)
- Custom conjugation available upon request
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Mouse anti-dog CD34 antibody, clone 1H6, recognizes the canine homologue of CD34, a glycosylated type I transmembrane protein (~110 kDa) expressed on endothelial cells and hematopoietic stem cells (McSweeney et al., 1998).
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on many stem cell populations. It serves as a stem cell marker and may function as a surface receptor involved in receptor-mediated endocytosis, adhesion, differentiation, and proliferation of hematopoietic stem cells.
CD34 may mediate attachment of stem cells to the bone marrow extracellular matrix or stromal cells and could act as a scaffold for lineage-specific glycans, facilitating binding to lectins. The intracellular domain is phosphorylated by protein kinase C, suggesting a role in signal transduction.
Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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