Thermo Fisher Scientific CRX Polyclonal Antibody
CRX 단백질을 인식하는 염소 유래 다클론 항체로, Western blot 및 IHC(Paraffin) 분석에 적합. 인간과 랫트 반응성, 액상 형태로 제공되며 0.5 mg/mL 농도. 시퀀스 상 유사성으로 인간, 마우스, 돼지, 소에도 반응 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DPLDYKDQSAWK, from internal region near the C-terminus of CRX (aa 284–295) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2554463 |
Product Specific Information
- Predicted to react with human, mouse, pig, and cow based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that regulates expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin.
CRX binds the OTX motif (TAATCC/A) upstream of photoreceptor genes and is also expressed in pinealocytes, where it may regulate melatonin synthesis genes and circadian rhythm.
Mutations in the CRX gene are associated with cone-rod dystrophy (CORD), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP).
The human CRX gene is located on chromosome 19q13.3 within the cone-rod dystrophy-2 locus (CORD2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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