Thermo Fisher Scientific Kaiso Recombinant Rabbit Monoclonal Antibody (ARC2086)
Kaiso 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, ICC/IF, ELISA, IP 등 다양한 응용에 적합합니다. 인간 및 랫트 반응성, HEK293 발현, IgG 동형이며, 고순도 친화 크로마토그래피 정제 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2086 |
| Immunogen | Synthetic peptide corresponding to amino acids 573–672 of human Kaiso/ZBTB33 (UniProt ID: Q86T24) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.04 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898016 |
Product Specific Information
- Positive Samples: A-549, SH-SY5Y, Rat brain
- Immunogen sequence:
HSQDPSGDSK LYRLHPCRSL QIRQYAYLSD RSSTIPAMKD DGIGYKVDTG KEPPVGTTTS TQNKPMTWED IFIQQENDSI FKQNVTDGST EFEFIIPESY
Target Information
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and to the non-methylated consensus KAISO-binding site TCCTGCNA.
The protein contains an N-terminal POZ/BTB domain and three C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters.
It may repress target genes of the Wnt signaling pathway and can also activate transcription of certain genes via recruitment of catenin delta-2 (CTNND2).
Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA.
Additionally, it interacts with the nuclear import receptor Importin-alpha 2 (karyopherin alpha2), which may mediate nuclear import. Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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