Thermo Fisher Scientific Desmin Recombinant Rabbit Monoclonal Antibody (ARC0235)
Desmin 단백질을 검출하기 위한 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, 높은 특이성과 재현성을 제공합니다. 연구용으로 근육 관련 단백질 분석에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0235 |
| Immunogen | Synthetic peptide corresponding to amino acids 371–470 of human Desmin (P17661) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898014 |
Product Specific Information
- Positive Samples: C2C12, RD, Mouse lung, Mouse heart, Rat heart
- Immunogen Sequence:
EEEIRHLKDE MARHLREYQD LLNVKMALDV EIATYRKLLE GEESRINLPI QTYSALNFRE TSPEQRGSEV HTKKTVMIKT IETRDGEVVS EATQQQHEVL
Target Information
Desmin (approximately 53 kDa) is a muscle-specific intermediate filament protein expressed in cardiac, skeletal, and smooth muscle cells. Its expression is regulated in a stage- and tissue-specific manner, being induced during terminal muscle cell differentiation. In skeletal and cardiac muscle, desmin localizes to the Z-disk and intercalated disk, while in smooth muscle its distribution is more heterogeneous. Coexpression with vimentin has been observed in muscle-derived tumors such as rhabdomyosarcomas and leiomyosarcomas. Altered desmin distribution is also associated with myocardial dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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