Thermo Fisher Scientific ATG4C Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:5000

Immunohistochemistry (IHC)

• Tested Dilution: 1:200–1:5000

Product Specifications

Product Specific Information

• Reconstitute with 150 µL of distilled water.
• Centrifuge to remove any insoluble material.

Target Information

ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are degraded intracellularly.
Autophagy is essential for cell homeostasis, differentiation, metamorphosis, non-apoptotic cell death, and aging.
Reduced autophagy levels have been observed in some malignant tumors, suggesting a role in regulating uncontrolled cell growth linked to cancer.

This gene encodes a member of the autophagin protein family, also designated as part of the C-54 family of cysteine proteases.
Alternate transcriptional splice variants encoding the same protein have been characterized.
ATG4C cleaves the C-terminal part of MAP1LC3, GABARAPL2, or GABARAP, liberating form I, which can be converted to form II.
Form II, with a revealed C-terminal glycine, is the PE-conjugated form capable of binding to autophagosomes.
ATG4C is highly expressed in skeletal muscle, heart, liver, and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.