Thermo Fisher Scientific SCNN1A Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: SCNN1A.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share a common structure with two short intracellular termini, two transmembrane segments, and a large extracellular loop containing a conserved cysteine-rich region.
There are three homologous isoforms of ENaC: alpha, beta, and gamma. ENaC in the kidney, lung, and colon plays a critical role in sodium and fluid homeostasis and mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure.
ENaC function is partly regulated via association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Gain-of-function mutations in beta- or gamma-ENaC can result in severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism type 1 (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.