Thermo Fisher Scientific Nav1.8 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Nav1.8 (SCN10A). Validated for WB and IHC-P. Lyophilized, unconjugated form. Suitable for neuropathic pain and sodium channel research. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000 |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human Nav1.8 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Nav1.8
Target Information
Gene: SCN10A
Protein: Nav1.8 (tetrodotoxin-resistant voltage-gated sodium channel alpha subunit)
Scn10a mediates voltage-dependent sodium ion permeability in excitable membranes, forming sodium-selective channels that open or close in response to voltage changes. It plays a key role in neuropathic pain mechanisms.
Members of the Deg/ENaC superfamily share structural similarity, featuring two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region. ENaC isoforms (α, β, γ) are essential for sodium and fluid balance in kidney, lung, and colon, and are regulated partly via CFTR interaction.
Associated Diseases:
- Episodic Pain Syndrome, Familial, 2
- Sodium Channelopathy-Related Small Fiber Neuropathy
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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