Thermo Fisher Scientific EGFR Recombinant Rabbit Monoclonal Antibody (30H45L48), Alexa Fluor 647

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated: 700308
• Alexa Fluor 488: MA7-00308-A488
• Alexa Fluor 555: MA7-00308-A555
• Request custom conjugation

Product Specific Information

This antibody is predicted to react with canine, mouse, and rat based on sequence homology.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Key advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression is associated with multiple cancer types, making EGFR a therapeutic target for biological and small molecule inhibitors.
The EGFR gene is located on chromosome 7 in humans and belongs to the HER/ERbB family, which includes ERbB2, ERbB3, and ERbB4. Upon ligand binding (e.g., EGF, TGF-α), EGFR dimerizes and undergoes autophosphorylation, initiating downstream signaling. Overexpression has been observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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