Thermo Fisher Scientific Uromodulin Polyclonal Antibody
Thermo Fisher Scientific의 Uromodulin Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 토끼 유래 다클론 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 완충액에 보관됩니다. 연구용 전용 제품입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human Uromodulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720349 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity is >95% (by SDS-PAGE).
Target Information
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinositol-anchored counterpart located on the luminal surface of the loop of Henle.
Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids and may provide defense against urinary tract infections caused by uropathogenic bacteria.
Defects in this gene are associated with autosomal dominant renal disorders such as medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN), characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure.
Several transcript variants exist, with two major variants encoding the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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