Thermo Fisher Scientific E-cadherin Polyclonal Antibody
E-cadherin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. Human과 Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 세포 접착 및 암 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:10,000 | View 11 publications |
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 4 publications |
| Immunoprecipitation (IP) | 1:100–1:500 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 338–649 of Human E-cadherin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.09 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549651 |
Product Specific Information
- Recommended positive controls: 293T, PC-12, MCF-7
- Predicted reactivity: Rat (80%), Pig (82%), Bovine (83%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (calcium-dependent adhesion protein) superfamily.
This calcium-dependent cell-cell adhesion glycoprotein consists of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the CDH1 gene (chromosome 16) are associated with gastric, breast, colorectal, thyroid, and ovarian cancers.
Loss or reduction of E-cadherin expression correlates with tumor invasion and metastasis potential.
The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is essential for internalization.
E-cadherin plays a critical role in tissue architecture and integrity by regulating cell growth and development.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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