Thermo Fisher Scientific FceR1 alpha Monoclonal Antibody (MAR-1), FITC, eBioscience
FcεRI alpha(FceR1α) 단백질을 인식하는 마우스 반응성 단클론 항체로, FITC로 표지되어 있습니다. Flow cytometry에 최적화되었으며, IgE 매개 알레르기 반응 연구에 유용합니다. 0.5 mg/mL 농도의 액상 형태로 제공되며 4°C 암소 보관이 권장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 3 |
| Immunohistochemistry (IHC) | - | 1 |
| Immunocytochemistry (ICC/IF) | - | 2 |
| Flow Cytometry (Flow) | 0.125 µg/test | 62 |
| Immunoprecipitation (IP) | - | 1 |
| Functional Assay | - | 1 |
| In vitro Assay | - | 2 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MAR-1 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465307 |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- Functional Grade
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Request custom conjugation available
Product Specific Information
Description:
The MAR-1 monoclonal antibody reacts with the Fc epsilon Receptor I alpha subunit (FcεRIα), an IgE-binding subunit that lacks signal-transducing ability. It is expressed on mast and basophil cells and is up-regulated in the presence of IgE. FcεRIα forms a tetrameric complex with one beta and two gamma subunits containing immunoreceptor tyrosine-based activation motifs (ITAMs). The FcεRI complex is critical in triggering IgE-mediated allergic reactions.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of the MC/9 mouse mast cell line. Recommended ≤0.125 µg per test (100 µL total volume). Optimal antibody concentration should be titrated per assay.
Optical Properties:
- Excitation: 488 nm
- Emission: 520 nm
- Laser: Blue Laser
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
FceR1 (Fc epsilonR1 alpha) is a subunit of the high-affinity IgE receptor. The receptor is a tetrameric complex consisting of one alpha, one beta, and two gamma subunits. The alpha subunit binds IgE, while the beta and gamma subunits mediate signal transduction. Crosslinking of IgE-bound receptors by allergens triggers release of mediators such as histamine, leading to allergic responses including hay fever and asthma. The receptor thus plays a central role in IgE-mediated hypersensitivity and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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