Thermo Fisher Scientific ATXN10 Polyclonal Antibody
ATXN10 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 반응성. PBS/glycerol buffer에 보관되며 -20°C에서 안정적. 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 346–475 of human ATXN10 (NP_037368.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.46 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914462 |
Product Specific Information
- Positive test controls: HeLa, SKOV3, LO2, HL-60, 293T, Mouse heart, Mouse kidney, Mouse liver, Rat testis
- Subcellular localization: Cytoplasm, perinuclear region
Immunogen sequence:
ETTNIFSNCG CVRAEGDISN VANGFKSHLI RLIGNLCYKN KDNQDKVNEL DGIPLILDNC NISDSNPFLT QWVIYAIRNL TEDNSQNQDL IAKMEEQGLA DASLLKKVGF EVEKKGEKLI LKSTRDTPKP
Target Information
The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and varying signs from other components of the nervous system.
A commonly accepted classification (Harding, 1993) divides ADCAs into three groups based on associated symptoms such as brainstem signs or retinopathy:
- ADCA I: presence of pyramidal/extrapyramidal symptoms and ophthalmoplegia
- ADCA II: presence of retinopathy
- ADCA III: absence of associated signs
Genetic and molecular analyses reveal that ADCAs are genetically heterogeneous even within subtypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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