Thermo Fisher Scientific Endostatin Monoclonal Antibody (1837-46)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-40230 detects Endostatin from human samples.
It has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), immunohistochemistry (paraffin), and Western blot applications.
For staining of paraffin sections, antigen retrieval (microwave irradiation <2×7 minutes> in citrate buffer) is advised.
The MA1-40230 immunogen is human endostatin.

Target Information

Endostatin evokes non-uniform responses in proliferation, cell adhesion, and migration of endothelial cells, suggesting that its effects depend on cell type.
It inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells.
Local delivery of endostatin reduces tumor-associated microvessel density, diameter, and functionality, thereby limiting tumor cell migration and invasion.
Endostatin is non-toxic, does not induce acquired drug resistance, and is considered a promising therapy for solid tumors, including gliomas.
Its anti-angiogenic activity is mediated partly by Zn²⁺ binding and elastase processing.
Endostatin is expressed in elastic fibers of vessel walls and basement membranes, and is released by neurons to accumulate in amyloid plaques in Alzheimer’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.