Thermo Fisher Scientific CD71 (Transferrin Receptor) Monoclonal Antibody (R17217 (RI7 217.1.4)), FITC, eBioscience
마우스 CD71(Transferrin Receptor)을 인식하는 단클론 항체로, FITC 형광 표지되어 있습니다. 세포 성장 및 철 대사 연구용으로 적합하며, 유세포분석(Flow Cytometry)에 최적화되어 있습니다. 0.5 µg/test 권장, 4°C 암소 보관.
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카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD71 (Transferrin Receptor) Monoclonal Antibody (R17217 (RI7 217.1.4)), FITC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View 30 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Fish, Mouse, Rat |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | R17217 (RI7 217.1.4) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465123 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Red 755
- NovaFluor Yellow 690
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The R17217 monoclonal antibody reacts with mouse CD71, a 170–180 kDa type II transmembrane protein. CD71 (transferrin receptor) exists as a homodimer on the cell surface and is essential for cellular growth. It is expressed by immature proliferating cells and at low levels on resting mature lymphocytes. Antigen or mitogen stimulation of T and B cells increases CD71 expression, and expression levels may vary among mouse strains.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Flow cytometric analysis of mouse bone marrow cells
- Recommended ≤ 0.5 µg/test in 100 µL final volume
- Cell number: 10⁵–10⁸ cells/test (empirically determined)
- Optimize titration for best performance
- Excitation: 488 nm
- Emission: 520 nm
- Laser: Blue Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Acidification of endosomes releases iron, after which the apotransferrin-receptor complex recycles to the cell surface. The transferrin receptor is essential for erythrocyte and nervous system development. Serum transferrin receptor (sTfR) is used to detect erythropoietin (EPO) misuse and as a diagnostic marker for various anemias, including those associated with rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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