Thermo Fisher Scientific NOTCH2 Recombinant Superclonal Antibody (18HCLC)

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, and Sheep.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of multiple different recombinant monoclonal antibodies, providing both the sensitivity of polyclonal antibodies and the specificity of monoclonal antibodies, with the consistency of recombinant production.
While functionally similar to polyclonal antibodies—recognizing multiple epitope sites on the target and delivering higher detection sensitivity for low-abundance targets—Superclonal™ antibodies have a known mixture of light and heavy chains, ensuring reproducibility across lots.
Formerly called “Recombinant polyclonal antibody,” this product is now rebranded as “Recombinant Superclonal™ antibody.” The physical product and performance remain unchanged.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a conserved protein in the Notch signaling pathway. It is a type I transmembrane protein with multiple EGF-like repeats in its extracellular domain and various domains in its intracellular region.
NOTCH2 acts as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1, regulating cell-fate determination.
Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity and cholestasis, along with cardiac, skeletal, and ophthalmologic manifestations. Facial features are characteristic, with occasional renal and vascular involvement.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.