Thermo Fisher Scientific UFD1L Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299, mouse lung
• Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (86%), Xenopus laevis (91%), Chicken (94%), Rhesus Monkey (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, which then promotes proteolytic degradation by the 26S proteasome.
Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
UFD1L, the human homolog of yeast UFD1, attenuates degradation of Ub-fusions with substitutions at Gly76.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a developmental role for this proteolytic pathway.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.