Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI3A12)
인간 CD137(TNFRSF9)을 인식하는 Mouse IgG1 단일클론 항체로, Flow Cytometry에 적합합니다. HEK293T 세포에서 발현된 재조합 단백질을 면역원으로 사용하였으며, 비접합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A12 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling maintains the survival and clonal expansion of activated T cells and CD8+ memory T cells, while suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces cytokine release regulating peripheral monocyte survival. Soluble forms of CD137 may provide a negative feedback mechanism for immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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