Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI3B7)
인간 CD137(TNFRSF9, 4-1BB)에 특이적인 단클론 항체로, Flow Cytometry에 적합합니다. 마우스 IgG1 형이며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, -20°C 보관, 연구용 전용 시약입니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:100
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B7 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling maintains the survival of activated T cells and CD8+ memory T cells, promotes clonal expansion, and suppresses myelopoiesis and dendritic cell development. Triggering CD137 induces cytokine release regulating peripheral monocyte survival. Soluble forms of CD137 may provide a negative control mechanism for certain immune responses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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