Thermo Fisher Scientific Arginase 1 (ARG1) Monoclonal Antibody (OTI3C8)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:30,000

Product Specifications

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are important for cell proliferation and detoxification. By degrading arginine, Arginase 1 deprives nitric oxide synthase of its substrate, down-regulating NO production.
Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells in both human and mouse. In human, expression is seen in blood neutrophils but not CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 may be expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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