Thermo Fisher Scientific NK1.1 Monoclonal Antibody (PK136), APC, eBioscience
Mouse NK1.1 항원을 인식하는 PK136 단클론 항체로, APC 형광체가 결합되어 NK 세포 및 특정 T 세포 분석에 적합. Flow cytometry에 최적화되어 있으며, 0.125 µg/test로 사용. C57BL/6 등 NK1.1 발현 마우스 균주에 적용 가능.
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Thermo Fisher Scientific NK1.1 Monoclonal Antibody (PK136), APC, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry | 0.125 µg/test | View 111 publications |
| Functional Assay | - | View 1 publication |
| Miscellaneous PubMed | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PK136 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_469477 |
Available Formats
- Unconjugated
- Alexa Fluor 561, 660, 700
- APC-eFluor 780
- Biotin
- Brilliant UV & Violet series (395–805)
- eFluor 450, FITC, PE, PE-Cyanine7, PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright series (436–780)
- Functional Grade
- Request custom conjugation available
Product Specific Information
The PK136 monoclonal antibody reacts with mouse NK1.1, an antigen expressed by natural killer cells and a subset of T cells in NK1.1-positive mouse strains (e.g., C57BL/6, NZB). Strains such as BALB/c, SJL, AKR, CBA, C3H, and A do not express NK1.1; for these, use the DX5 antibody (Product #14-5971).
Simultaneous staining of C57BL/6 spleen cells with PK136 and DX5 shows coexpression of both markers in most cells, with small populations of DX5+PK136− and DX5−PK136+ cells.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on C57BL/6 mouse splenocytes, ≤0.125 µg/test (100 µL final volume). Optimize antibody titration for best performance.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
NK1.1 (KLRB1, NKR-P1A, CD161) is expressed by Natural Killer (NK) cells, mediating cytotoxicity and cytokine secretion. The KLRB1 protein, a C-type lectin-like receptor, includes an extracellular lectin domain, transmembrane region, and cytoplasmic tail. It is classified as a type II membrane protein with an external C terminus. NKR-P1A recognizes Lectin Like Transcript-1 (LLT1) as its functional ligand.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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