Thermo Fisher Scientific GRP78 Polyclonal Antibody, Alexa Fluor 647
Alexa Fluor 647로 표지된 GRP78 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 사용 가능. Western blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. ER 단백질 GRP78 검출 및 세포 스트레스 연구에 유용.
- 카탈로그번호
- PA1014AA647
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: -
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–10 µg/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP78 |
| Conjugate | Alexa Fluor™ 647 |
| Excitation / Emission Max | 650 / 671 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662648 |
Product Specific Information
PA1-014A-A647 detects glucose regulated protein/BiP (GRP78) in human, rat, and mouse samples.
The immunogen is a synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP78.
Target Information
GRP78 is a 78 kDa glucose-regulated protein belonging to the heat shock protein family (HSP70).
It resides in the endoplasmic reticulum (ER) and transiently associates with newly synthesized secretory and membrane proteins.
GRP78 interacts with misfolded proteins, marking them for degradation, and contains a conserved Lys-Asp-Glu-Leu (KDEL) sequence for ER retention.
It plays a key role in protein folding, ER stress response, and prevention of apoptosis.
Altered GRP78 expression is associated with Alzheimer’s disease and drug resistance in cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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