Thermo Fisher Scientific extracellular MC4R Polyclonal Antibody
인간 MC4R의 세포외 도메인(aa 2-45)에서 유래한 합성 펩타이드를 면역원으로 한 Rabbit Polyclonal 항체입니다. Western blot 및 IHC에 사용 가능하며, 뇌에서의 MC4R 발현 연구에 적합합니다. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 2–45 of extracellular domain of human MC4R conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of MQ water. Centrifuge to remove any insoluble material.
- The peptide shares 89% identity with mouse sequence.
- Specificity: MC4R
Target Information
Expression of MC4R has been reported in brain. Unlike other melanocortin receptors, MC4R is not expressed in adrenal cortex or melanocytes.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices.
These receptors exist in active and inactive forms, with various ligands inducing conformational changes that trigger G-protein signaling cascades.
Negative regulation of GPCRs plays a key role in cellular physiology and pharmacological research, leading to the development of GPCR-targeted drugs such as Zyprexa and Claritin.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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