Thermo Fisher Scientific extracellular MC4R Polyclonal Antibody
MC4R 단백질의 extracellular domain(aa 90-130)에 특이적인 Rabbit Polyclonal Antibody. WB 및 IHC에 사용 가능하며 인간, 마우스, 랫트 반응성. Lyophilized 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Thermo Fisher Scientific extracellular MC4R Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 90–130 of extracellular domain of human MC4R conjugated to carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of MQ water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: MC4R.
Target Information
Expression of MC4R has been reported in the brain. Unlike other melanocortin receptors, MC4R is not expressed in adrenal cortex or melanocytes.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members predicted to exist. All GPCRs share a structural motif of seven membrane-spanning helices and exist in both active and inactive forms. Activating ligands induce conformational changes leading to G-protein signaling and downstream effects.
Studies have revealed mechanisms for negative regulation of GPCRs, which have significant implications for cellular physiology and pharmacological research. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) exemplify successful applications in mental health and allergy treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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