Thermo Fisher Scientific COX10 Polyclonal Antibody
Thermo Fisher Scientific COX10 Polyclonal Antibody는 인간 COX10 단백질을 인식하는 토끼 IgG 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
- 카탈로그번호
- PA556900
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COX10. Recombinant protein control fragment (Product #RP-95547). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640086 |
Product Specific Information
Immunogen sequence:
CVGGSVWYLE RRTIQDSPHK FLHLLRNVNK QWITFQHFSF LKRMYVTQLN RSHNQQVRPK PEPVASPFLE KTSSGQAKAE IYEMRP
Highest antigen sequence identity to the following orthologs:
- Mouse: 64%
- Rat: 66%
Target Information
Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D), also known as cytochrome c oxidase deficiency.
This disorder affects the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease.
Features may include hypertrophic cardiomyopathy, hepatomegaly, liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, and mental retardation.
A subset of patients may manifest Leigh syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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