Thermo Fisher Scientific ALK Monoclonal Antibody (OTI6G9), TrueMAB
ALK 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 적합. Human 시료 반응성. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도. 뇌 발달 관련 연구 및 종양 유전자 변이 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with several tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
The NPM-ALK fusion gene, resulting from chromosomal translocation, produces an oncogenic protein.
ALK is a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK. It plays a key role in neuronal development and signaling.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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