Thermo Fisher Scientific CD137 (4-1BB) Monoclonal Antibody (17B5), Biotin, eBioscience
Mouse CD137(4-1BB) 인식하는 Syrian hamster 유래 단클론 항체로 Biotin 결합형. Flow cytometry 및 기능 분석에 적합하며, 활성화된 T세포 표면의 CD137 검출에 사용. 0.5 µg/test 권장, 4°C 암소 보관.
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Thermo Fisher Scientific CD137 (4-1BB) Monoclonal Antibody (17B5), Biotin, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry | 0.5 µg/test | View 11 publications |
| Functional Assay | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Syrian hamster / IgG |
| Recommended Isotype Control | Syrian Hamster IgG Isotype Control, Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17B5 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466604 |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Formats
Product Specific Information
The 17B5 monoclonal antibody reacts with mouse CD137 (4-1BB), a TNFR superfamily member expressed on activated T cells around day 4–6 after TCR activation. CD137 interaction with its ligand 4-1BBL delivers a costimulatory signal crucial for T cell–APC interaction. The 17B5 antibody shows strong antagonistic effects in functional assays.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Validated by flow cytometric analysis of activated mouse splenocytes at ≤0.5 µg/test (100 µL final volume). Optimal performance requires empirical titration (10⁵–10⁸ cells/test).
Target Information
CD137 (TNFRSF9, 4-1BB) is an inducible costimulatory molecule expressed primarily on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling supports activated and memory CD8⁺ T cell survival and proliferation, while modulating myelopoiesis and dendritic cell development. Soluble CD137 may act as a negative regulator of immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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