Thermo Fisher Scientific IL-17A Chimeric Recombinant Rabbit Monoclonal Antibody (MM17F3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is highly specific for murine IL-17A. In ELISA analysis, no cross-reactivity with IL-17B, IL-17C, IL-17D, IL-17E, or IL-17F was observed.

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa, disulfide-linked homodimer consisting of 136 amino acids and belongs to a six-member family (IL-17A–17F). It signals through the IL-17 receptor (IL-17R/CDw217).
Activated peripheral blood CD4+ T-cells produce high levels of IL-17A homodimer, which enhances ICAM-1 expression in human fibroblasts. Human IL-17A stimulates epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
In the presence of human IL-17A, fibroblasts can sustain proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, showing cross-species receptor recognition.
IL-17A regulates NF-kappa B and MAP kinase activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide (NO) production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.