Thermo Fisher Scientific IL-17A Recombinant Mouse Monoclonal Antibody (MM17F3)
마우스 IL-17A에 특이적인 재조합 단클론 항체로, ELISA 및 기능적 억제 분석에 적합합니다. HEK293 세포에서 발현되었으며, Protein A로 정제된 액상 형태입니다. 높은 특이성과 재현성을 제공하며 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| ELISA | Assay-dependent | - |
| Functional Assay | Assay-dependent | - |
| Inhibition Assays | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MM17F3 |
| Immunogen | This antibody was raised by immunising C57Bl/6 mice with IL-17A cross-linked to ovalbumin to generate a highly immunogenic complex. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074651 |
Product Specific Information
Specificity: This antibody is highly specific for murine IL-17A; in ELISA analysis, no cross-reactivity with IL-17B, IL-17C, IL-17D, IL-17E, or IL-17F was observed.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer consisting of 136 amino acids, belonging to a family of six related proteins (IL-17A–IL-17F) that signal through the IL-17 receptor (IL-17R/CDw217).
High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. IL-17A enhances expression of ICAM-1 in human fibroblasts and stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
In the presence of IL-17A, fibroblasts can sustain proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating cross-species receptor recognition.
IL-17A regulates NF-kappa B and MAP kinase activities, stimulates expression of IL-6 and COX-2, and enhances nitric oxide (NO) production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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