Thermo Fisher Scientific EpoR Recombinant Rabbit Monoclonal Antibody (004)
인체 EPOR 단백질을 인식하는 재조합 토끼 단클론 항체. ELISA에 적합하며 높은 특이성과 재현성을 제공. 보존제가 없는 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
- Application: ELISA
- Tested Dilution: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 004 |
| Immunogen | Recombinant Human EPOR Protein (Met1–Pro250) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786124 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Human EPOR.
Target Information
EpoR encodes the erythropoietin receptor, a member of the cytokine receptor family. Upon binding erythropoietin, it activates Jak2 tyrosine kinase, which triggers intracellular pathways including Ras/MAP kinase, PI3K, and STAT signaling. The activated receptor promotes erythroid cell survival.
Defects in this gene can cause erythroleukemia and familial erythrocytosis, while dysregulation may influence tumor growth. Multiple transcript variants exist due to alternate splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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