Thermo Fisher Scientific SOX11 Monoclonal Antibody (SOX11-C1), Biotin, eBioscience

Applications

Product Specifications

Additional Formats

• Unconjugated
• eFluor 660
• Request custom conjugation

Product Specific Information

The monoclonal antibody SOX11-C1 (C1) recognizes human Sox11, a member of the SOX (sex determining region Y-related HMG box) family of transcription factors. Sox11 is normally expressed in the developing central nervous system during embryogenesis and shares sequence homology with Sox4. It plays a role in neuronal maturation and epithelial-mesenchymal interactions and is essential for the survival of neuronal and mesenchymal progenitor cells.

Sox11 is expressed in mantle cell lymphoma (MCL), subsets of hairy cell leukemias, Burkitt lymphomas, and B cell lymphoblastic leukemias, but not in other B cell lymphomas or normal B lymphocytes. It is also expressed in epithelial ovarian cancer and gliomas.

Applications Reported:
This SOX11-C1 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections.

Applications Tested:
This antibody has been tested by immunohistochemistry on formalin-fixed paraffin-embedded tissue using high pH antigen retrieval and can be used at ≤10 µg/mL. It is recommended to titrate the antibody for optimal performance in the assay of interest.

Target Information

This intronless gene encodes a member of the SOX family of transcription factors involved in embryonic development and cell fate determination. The encoded protein may act as a transcriptional regulator by forming complexes with other proteins, functioning in the developing nervous system, and potentially playing a role in tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.