Thermo Fisher Scientific SOX11 Monoclonal Antibody (SOX11-C1), Biotin, eBioscience
SOX11 단백질을 인식하는 Biotin 결합 단클론 항체로, 인간 시료의 IHC(P) 및 WB 분석에 적합합니다. 신경 발달 및 종양 연구용으로 활용되며, 고순도의 액상 형태로 제공됩니다. 4°C 보관, 동결 금지.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SOX11-C1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572836 |
| Filtration | 0.2 µm post-manufacturing filtered |
Additional Formats
Product Specific Information
The monoclonal antibody SOX11-C1 (C1) recognizes human Sox11, a member of the SOX (sex determining region Y-related HMG box) family of transcription factors. Sox11 is normally expressed in the developing central nervous system during embryogenesis and shares sequence homology with Sox4. It plays a role in neuronal maturation and epithelial-mesenchymal interactions and is essential for the survival of neuronal and mesenchymal progenitor cells.
Sox11 is expressed in mantle cell lymphoma (MCL), subsets of hairy cell leukemias, Burkitt lymphomas, and B cell lymphoblastic leukemias, but not in other B cell lymphomas or normal B lymphocytes. It is also expressed in epithelial ovarian cancer and gliomas.
Applications Reported:
This SOX11-C1 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections.
Applications Tested:
This antibody has been tested by immunohistochemistry on formalin-fixed paraffin-embedded tissue using high pH antigen retrieval and can be used at ≤10 µg/mL. It is recommended to titrate the antibody for optimal performance in the assay of interest.
Target Information
This intronless gene encodes a member of the SOX family of transcription factors involved in embryonic development and cell fate determination. The encoded protein may act as a transcriptional regulator by forming complexes with other proteins, functioning in the developing nervous system, and potentially playing a role in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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