Thermo Fisher Scientific Caspase 9 Polyclonal Antibody

Thermo Fisher Scientific Caspase 9 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive control: Human liver tissue
• Cellular location: Cytoplasmic

Target Information

Caspase 9 (ICE-like apoptotic protease 6, ICE LAP6, apoptotic protease Mch6, apoptotic protease activating factor 3, Apaf3) is a member of the peptidase family C14 containing a CARD domain. Caspases are cysteine proteases expressed as inactive precursors that mediate apoptosis through proteolysis of specific substrates. Caspase 9 is active as a heterotetramer, present in the cytosol, and translocates to the mitochondria upon activation. It participates in the caspase activation cascade responsible for apoptosis execution and activates Caspase 3 and Caspase 6.

Binding of Caspase 9 to Apaf-1 leads to activation of the protease, which subsequently cleaves and activates Caspase 3. Caspase 9 promotes DNA damage-induced apoptosis in an ABL1/c-Abl-dependent manner and cleaves poly(ADP-ribose) polymerase (PARP). Caspase 9 is expressed in various human tissues. In rats, an isoform has been identified with an alternative C-terminal sequence. Mutations in Caspase 9 affect brain development; in mice, insufficient Caspase 9 causes abnormal cerebrum and neuron development. In humans, dysfunctional Caspase 9 expression varies by tissue, and low levels may contribute to cancer and neurodegenerative diseases such as Alzheimer’s Disease (AD).

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.

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