Thermo Fisher Scientific Human SLC22A17 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the carboxy terminus of human Slc22A17.
PEP-0663 can be used as a blocking peptide with polyclonal antibody PA5-20543.

Target Information

The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contains 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2.

Transporters of the SLC22 family function in different ways such as:

• Uniporters that mediate facilitated diffusion in either direction (OCTs)
• Anion exchangers (OAT1, OAT3, URAT1)
• Na(+)/L-carnitine cotransporter (OCTN2)

Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, performing homeostatic functions in brain and heart.

Mutations in the Slc22 family may cause diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may alter drug absorption or excretion. Recent studies show that Slc22A17, as a receptor for Lipocalin 2, is relatively highly expressed in hematopoietic stem cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.