Thermo Fisher Scientific Human LIMP2 Synthetic Peptide

Thermo Fisher Scientific Human LIMP2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to an 18 amino acid synthetic peptide from near the carboxy terminus of human LIMP2.
PEP-0664 can be used as a blocking peptide with polyclonal antibody PA5-20544.

Target Information

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene.
SR-BII differs from SR-BI in that the encoded C-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI.
SR-BII is abundant in tissues expressing SR-BI, including liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may act as a functional HDL receptor. SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, mediating selective lipid transfer between HDL and cells.
The relative expression and functional activities of these two isoforms may regulate selective lipid transfer between HDL and cells.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.