Thermo Fisher Scientific CD11b Monoclonal Antibody (M1/70)
CD11b 단백질의 세포 표면 발현을 검출하는 Rat 모노클로날 항체로, Human, Mouse, Rabbit 등 다양한 종에 반응. IHC, Flow Cytometry, ELISA 등 다중 응용 가능. Mac-1 인테그린 복합체 연구 및 면역세포 표지에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | 2 publications |
| Flow Cytometry (Flow) | 1 µg/mL | 24 publications |
| ELISA | - | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | 2 publications |
| Functional Assay | Assay-dependent | - |
| Miscellaneous PubMed | - | 32 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rabbit |
| Published Species | Human, Mouse, Rabbit |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M1/70 |
| Immunogen | B10 mouse spleen cells enriched for T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153179 |
Available Formats
- FITC conjugate: MA1-10081
- PE conjugate: MA1-10082
- Request custom conjugation
Product Specific Information
This antibody detects an extracellular epitope of CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes, and NK-cells. It associates with CD18 to form the Mac-1 integrin, which plays an important role in cell-cell interactions.
Endotoxin level is less than 0.01 EU/µg of protein, as determined by the LAL test.
Functional Application: Blocking.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 complex (Mac-1, CR3) acts as a receptor for ICAMs, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X, mediating cell-cell and cell-matrix interactions.
CD11b is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, subsets of NK and dendritic cells, and microglia. Expression increases during monocyte maturation and varies among tissue macrophages. It is commonly used as a microglial marker in nervous tissue.
Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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