Thermo Fisher Scientific CD11b Monoclonal Antibody (M1/70), PE
CD11b 단백질의 세포 표면 발현을 검출하는 PE-결합 단클론 항체. 인간, 마우스 등 다양한 종에 반응하며, 유세포분석(Flow Cytometry)에 적합. Mac-1 복합체 연구 및 단핵구/대식세포 마커로 활용 가능. 4°C 암소 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 1–2 µg/mL | View 7 publications |
| Miscellaneous PubMed (Misc) | – | View 6 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rabbit |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M1/70 |
| Immunogen | B10 mouse spleen cells enriched for T cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154207 |
Additional Formats
Product Specific Information
This antibody detects an extracellular epitope of CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes, and NK cells. It associates with CD18 to form the Mac-1 integrin complex, which plays an important role in cell-cell interactions.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3).
CD11b is expressed on the surface of:
- Monocytes/macrophages
- Granulocytes
- Activated lymphocytes
- A subset of NK cells and dendritic cells
- Microglia in the brain
Functions and Binding Partners:
- Acts as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X.
- Plays key roles in cell-cell and cell-matrix adhesion.
Expression Patterns:
- 8% of spleen cells
- 44% of bone marrow cells
- <1% of thymocytes
- Commonly used as a microglial marker in nervous tissue.
- Expression increases during monocyte maturation.
- Peritoneal macrophages express higher CD11b levels than splenic macrophages.
Associated Diseases:
- Systemic lupus erythematosus (SLE)
- ITGAM-related susceptibility to SLE
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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