Thermo Fisher Scientific GABRA4 Monoclonal Antibody (N398A/34)
GABRA4 단백질을 검출하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone N398A/34). Western blot, IHC, ICC/IF에 사용 가능하며, 인간·마우스·랫트 반응성. 비결합형, 고순도 Protein G 정제, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N398A/34 |
| Immunogen | Fusion protein amino acids 410–450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735192 |
Additional Formats
- APC conjugate: MA5-45733
- FITC conjugate: MA5-45734
- PE conjugate: MA5-45736
- PerCP conjugate: MA5-45735
- Custom conjugation available upon request
Product Specific Information
A 1:100 dilution of MA5-27701 was sufficient for detection of GABA-A R, Alpha4 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 60 kDa. Does not cross-react with other GABA-A-Receptor Alpha subunits.
This antibody was formerly sold as clone S398A-34.
Target Information
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain, acting at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
The GABRA4 gene encodes subunit alpha-4, which is involved in the etiology of autism and may increase autism risk through interaction with the gamma-aminobutyric acid receptor beta-1 subunit. Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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