Thermo Fisher Scientific Human JPH3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the carboxy terminus of human JPH3.
PEP-0763 can be used as a blocking peptide with polyclonal antibody PA5-20643.

Target Information

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of these junctional complexes.
JPs consist of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a cytoplasmic domain with specific affinity for the PM.

Four JP subtypes have been identified:

• JPH1: Expressed in skeletal muscle
• JPH2: Detected throughout all muscle cell types
• JPH3, JPH4: Predominantly expressed in the brain

In the CNS, JPH3 and JPH4 are expressed throughout neural sites and contribute to subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 exhibit impaired learning, memory, and abnormal nervous functions.
A repeat expansion in JPH3 is associated with Huntington disease-like 2.
At least two isoforms of JPH3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.