Thermo Fisher Scientific GCK Polyclonal Antibody
Thermo Fisher Scientific의 GCK Polyclonal Antibody는 인간 GCK 단백질에 특이적으로 반응하는 토끼 IgG 기반 항체입니다. IHC(P) 및 ICC/IF 실험에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GCK. Recombinant protein control fragment (Product #RP-89751) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789434 |
Product Specific Information
Immunogen sequence:
RLVDENLLFH GEASEQLRTR GAFETRFVSQ VESDTGDRKQ IYNILSTLGL RPSTTDCDIV RRACESVSTR AAHMCSAGLA GVINRMRESR SEDVMRITVG VDGSVYKLHP SFKERFHA
Target Information
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase—one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. Unlike other hexokinases, this enzyme remains active while glucose is abundant and is not inhibited by glucose-6-phosphate. Mutations in this gene are associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young (MODY2), and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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