Thermo Fisher Scientific 4-1BB Ligand Recombinant Rat Monoclonal Antibody (AT113-2)
Thermo Fisher의 4-1BB Ligand Rat Monoclonal Antibody (AT113-2)는 마우스 4-1BBL을 특이적으로 인식하는 항체로, WB, Flow Cytometry, Inhibition Assay에 사용됩니다. Recombinant 형식으로 높은 특이성과 재현성을 제공하며, 단기 4°C 보관 및 장기 -20°C 보관이 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| Inhibition Assays (IA) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AT113-2 |
| Immunogen | This antibody was raised by immunising LOU rats with soluble recombinant 4-1BBL:Fc fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074595 |
Product Specific Information
Specificity: This antibody is specific for 4-1BB ligand (also known as CD137 ligand), which is a member of the TNF superfamily and is a type II membrane protein.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on various cells including inflamed endothelial cells, where its expression enhances extravasation of CD137L-expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is expressed in most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma) but absent in Hodgkin and T-cell lymphomas. It is also expressed in carcinoma cell lines and may be involved in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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