Thermo Fisher Scientific CD193 (CCR3) Monoclonal Antibody (eBio5E8-G9-B4 (5E8-G9-B4)), eBioscience

Applications

• Flow Cytometry (Flow)
  • Tested Dilution: 1 µg/test
  • Publications: View 1 publication

Product Specifications

Additional Formats

• Alexa Fluor 488
• Alexa Fluor 700
• APC
• PE
• Request custom conjugation

Product Specific Information

The eBio5E8-G9-B4 monoclonal antibody reacts with human CD193 (CCR3, CKR3). CD193 is a member of the seven-transmembrane G-protein coupled receptor (GPCR) family and serves as a high-affinity receptor for chemokines such as eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26), and MCP-4 (CCL13). It can also bind RANTES, MCP-3, and MCP-4.

CD193 is highly expressed on eosinophils and plays a key role in their migration and function. It is also found on CD4+ TH2 cells, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitors, and airway epithelial cells. CD193 is implicated in allergic airway inflammation and asthma and can act as a receptor for HIV-1 cell entry.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested on normal human peripheral blood; recommended ≤1 µg/test (100 µL reaction volume). Optimize titration for desired assay.

Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CCR3 (C-C chemokine receptor type 3) binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1 delta. It transduces signals by increasing intracellular calcium ion levels and serves as an alternative co-receptor with CD4 for HIV-1 infection. Chemokines play critical roles in inflammation and immune cell recruitment through G protein-coupled receptors, which are divided into CXCR and CCR subfamilies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.