Thermo Fisher Scientific E2F6 Monoclonal Antibody (1F7-A9)
Thermo Fisher Scientific의 E2F6 Monoclonal Antibody (1F7-A9)는 인간 E2F6 단백질을 표적하는 Mouse IgG2a 항체로, WB, ICC/IF, ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS 버퍼 기반, 무보존제, 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F7-A9 |
| Immunogen | E2F6 (AAH08348, amino acids 1–281) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY VSMRKALKVK RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIDLVEKKS KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL SAMEDALDEL IKDCAQQLFE LTDDKENERL AYVTYQDIHS IQAFHEQIVI AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ GQTSNKRSEG VGTSSSESTH PEGPEEEENP QQSEELLEVS N
Target Information
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and in the action of tumor suppressor proteins. They are also targets of the transforming proteins of small DNA tumor viruses.
Many E2F proteins contain several conserved domains: a DNA-binding domain, a dimerization domain for interaction with DP proteins, a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain embedded within the transactivation domain.
The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and acts as an inhibitor of E2F-dependent transcription. The protein is part of a multimeric complex containing a histone methyltransferase and transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, though their validity as isoforms is not clearly demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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