Thermo Fisher Scientific E4F1 Monoclonal Antibody (4B10)
E4F1 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot, ICC/IF, ELISA에 적합합니다. 인간 반응성으로, 액상 형태이며 PBS 버퍼에 보존제 없이 제공됩니다. 세포 생존, 증식 및 p53/pRB 경로 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B10 |
| Immunogen | E4F1 (NP_004415.2, amino acids 685–784) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GHQIIVQNVT MDEETALGPE AAAADTITIA TPESLTEQVA MTLASAISEG TVLAARAGTS GTEQATVTMV SSEDIEILEH AGELVIASPE GQLEVQTVIV
Target Information
May function as a transcriptional repressor and as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Plays roles in cell survival and proliferation through regulation of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates cyclin CCNA2 transcription.
Identified as a cellular target of the adenoviral oncoprotein E1A, required for both transcriptional activation and repression of viral genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: H00001877-M03_E4F1_Q66K89-1_House_mouse.svg, H00001877-M03_E4F1_Q66K89-1_House_mouse_PDP.jpeg)
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