Thermo Fisher Scientific E2F6 Monoclonal Antibody (S1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein Sequence:

MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY VSMRKALKVK RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIDLVEKKS KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL SAMEDALDEL IKDCAQQLFE LTDDKENERL AYVTYQDIHS IQAFHEQIVI AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ GQTSNKRSEG VGTSSSESTH PEGPEEEENP QQSEELLEVS N

Target Information

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and in the action of tumor suppressor proteins. They are also targets of transforming proteins of small DNA tumor viruses.

Many E2F proteins contain several evolutionarily conserved domains:

• DNA binding domain
• Dimerization domain (interaction with DP proteins)
• Transactivation domain enriched in acidic amino acids
• Tumor suppressor protein association domain (embedded within the transactivation domain)

The encoded E2F6 protein is atypical because it lacks the transactivation and tumor suppressor protein association domains. Instead, it contains a modular suppression domain and acts as an inhibitor of E2F-dependent transcription. It is part of a multimeric protein complex containing a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported, though their validity as isoforms has not been clearly demonstrated.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.